Editorial: Role of NOD-Like Receptors in Infectious and Immunological Diseases
نویسندگان
چکیده
منابع مشابه
Toll-like receptors and NOD-like receptors in rheumatic diseases
The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spo...
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The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avoiding extensive tissue damage. Nucleotide-binding oligomerization domain-like ...
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Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane receptors, NLRs are cytoplasmic receptors that play a crucial role in the innate immune response by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Based on the...
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Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly conserved cytosolic pattern recognition receptors that perform critical functions in surveying the intracellular environment for the presence of infection, noxious substances, and metabolic perturbations. Sensing of these danger signals by NLRs leads to their oligomerization into large macromolecular scaffolds an...
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Rodrigo Siqueira-Batista1, Mauro Geller2 and Andréia Patrícia Gomes3 1Professor of Internal Medicine, Neuroscience and Immunology/Microbiology, Centro Universitário Serra dos Órgãos (UNIFESO); 2Professor of Immunology and Microbiology, Centro Universitário Serra dos Órgãos (UNIFESO); Coordinator of Genodermatosis, Genetic Services, Instituto Puericultura e Pediatria Martagão Gesteira (IPPMG), F...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00923